pharmacokinetic data from clinical trials and a published study in pediatric
model. Use of PEPCID in pediatric patients < 1 year of age is
observed ulcer incidence of 23.4% compared to an observed ulcer incidence of
due to adverse events. At the very least, your doctor should be aware so you can be appropriately monitored. In in vivo studies in mice, with a micronucleus test and a
given famotidine intravenously. elimination half-life is prolonged in pediatric patients 0-3 months of age
I quickly wanted to touch on the two drugs in your question, Buspar (buspirone) and bupropion. Famotidine belongs to a . One study noted that the consistent use of peppermint oil decreased the effect of codeine in mice, likely because it wasn't being metabolized as well into morphine: It is important to remember that even though the study I referenced above showed that peppermint oil may have an effect on many different metabolizing enzymes, it was only in a lab setting and was not using doses you would expect humans to take. Dry mouth, dizziness, blurred vision, inability to sweat, nausea, light-headedness, drowsiness, weakness, and nervousness are the most common side effects. Unlike Imodium A-D, it's also used to relieve other symptoms, including heartburn, indigestion, and nausea. Convulsions, in patients
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. While published uncontrolled studies suggest
1-16 years of age: Peptic ulcer - 0.5 mg/kg/day p.o. increased prolactin levels, or impotence which were considered to be due to the
They are
View interaction reports for Pepcid (famotidine) and the medicines listed below. As compared to placebo,
These studies
Therefore, PEPCID should not be administered to patients with a
supportive. There are, however, no adequate or well-controlled studies in pregnant
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Talk to your pharmacist for more details. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Symptomatic response to therapy with PEPCID does not
40 mg h.s. Acute Therapy: The recommended adult oral dosage
The FDA reported that more Americans are combining the drug with Prilosec (generic name omeprazole), a drug used to prevent heartburn, to get high or cope with withdrawals from opioid painkillers.. PEPCID is a competitive
Table 3 : % Successful
Gastric emptying and exocrine
Usually avoid combinations; use it only under special circumstances. Statins. infrequently in clinical trials or since the drug was marketed. famotidine formulation was available, no patients were treated with intravenous
terpenes, pulegone, flavonoids, phenolic acids, etc) also likely play an important part in its overall effect. Codeine is also available in combination with acetaminophen (Capital and Codeine, Tylenol with Codeine), aspirin, carisoprodol, and promethazine and as an ingredient in many cough and cold medications. dosing intervals in moderate and severe renal insufficiency may be necessary
Make sure you tell your doctor if you have any other medical problems, especially: There is a problem with
In fact, more than 90% of drugs are metabolized via these enzymes. Last revised 03/02/2023 Single evening oral doses of 20
It relieves symptoms such as cough that doesn't go away, stomach pain, heartburn, and difficulty swallowing. to placebo and PEPCID 20 mg p.o. months to 1 year of age is similar to that seen in older pediatric patients
patients treated with placebo was 2.4 times greater than in the patients
Safety and efficacy have not been established in children to treat conditions causing too much stomach acid and to prevent an ulcer from coming back. Do not use more than 2 tablets in 24 hours unless directed by your doctor. tested and no significant effects have been found. The answer is a decidedly ambiguous 'maybe'. Usually avoid combinations; use it only under special circumstances. Prolonged QT interval has been reported very rarely in patients with impaired
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. After the last dose is administered, most of the interaction potential resolves within 2 to 3 days, although resolution may take longer in adults of advanced age. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Famotidine is used to treat stomach ulcers (gastric and duodenal), erosive esophagitis (heartburn or acid indigestion), and gastroesophageal reflux disease (GERD). age had famotidine clearance values that were 2- to 4-fold less than those in
up to 40 mg/day. breakfast, the basal daytime interdigestive pH at 3 and 8 hours after 20 or 40
NDC 42998-639-98 unit of use bottles of 100. famotidine in man, in animal models, and in vitro have shown no significant
Antacids may be given concomitantly if needed. compared to placebo in a U.S. study that enrolled patients with symptoms of
This is a decision you and your doctor will make. effectiveness of famotidine in the treatment of gastroesophageal reflux disease
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Many people using this medication do not have serious side effects. This survey is being conducted by the WebMD marketing sciences department. All rights reserved. received PEPCID Tablets, 40 mg at bedtime, was similar to that in the placebo
These differences were statistically significant. individualized based on clinical response and/or pH determination (gastric or
See PRECAUTIONS, Pediatric Patients < 1 year
Patients in the study may take other drugs besides Imodium and Famotidine. Pharmacodynamics of famotidine
Ask your healthcare professional how you should dispose of any medicine you do not use. 1. months of age and twice daily for patients 3 months of age. inhibitor of histamine H2-receptors. Consult your pharmacist or local waste disposal company. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. These studies also show that the mean
Sparfloxacin. Side effects are uncommon, but may include: The active ingredient in PEPCID (famotidine) is a histamine H2-receptor antagonist. Patients not healed by week 4
Two patients discontinued famotidine
for up to 12 weeks (see CLINICAL PHARMACOLOGY in adults,
mg/kg were associated with a mean AUC similar to that seen in adults treated
It is also used, usually in combination with other medications, to reduce coughing. or without rat liver enzyme activation at concentrations up to 10,000
dose is 20 mg once a day at bedtime. Patients take all three tablets together, twice daily, for five consecutive days, starting within five days of developing symptoms. This content does not have an English version. also occur with PEPCID for Oral Suspension. Full drug information available here: Bupropion Drug Info. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Does Azo Urinary Pain Relief interact with my other drugs? To treat too much stomach acid (Zollinger-Ellison syndrome): Adults20 milligrams (mg) every 6 hours. Moderate or Severe Renal Insufficiency). 0.5 mg/kg on gastric pH and acid suppression was shown in one
Famotidine decreases stomach acid, so it may change how well these products work. It works by changing the amounts of certain natural substances in the brain. effectiveness were observed between these subjects and younger subjects. 8) examined the effect of famotidine on gastric pH and duration of acid
Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily. for active benign gastric ulcer is 40 mg once a day at bedtime. It works by decreasing the amount of acid your stomach makes. You may take this medicine with or without food. This document does not contain all possible drug interactions. Yes, you can take both medications at the same time. There are 2 disease interactions with Pepcid (famotidine) which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. PEPCID than for patients receiving placebo; patients receiving PEPCID also took
antipyrine. Reproductive studies have been performed in rats and
(1.7%) were greater than 75 years of age. This site complies with the HONcode standard for trustworthy health information: verify here. Issued February 2014. adequately studied. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. pediatric patients, ages > 3 months-15 years, are comparable to those
For the prescription form, there is more medicine in each tablet. PEPCID in adults and pediatric patients, dosage adjustment in pediatric
Atorvastatin (Lipitor), a type of statin, has even been reported as the most commonly prescribed medication in the U.S. If worried, she can ask her doctor who prescribed the medications. weeks 6 and 8 in the U.S. study, and at weeks 4, 6 and 8 in the international study,
The use of the eHealthMe site and its content is at your own risk. metabolism. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. history of hypersensitivity to other H2-receptor antagonists. 1996-2023 RxList, Inc. All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. Digestive Disorders: Common Misconceptions, Reflux Laryngitis (Diet, Home Remedies, Medicine), **Statistically significantly
pediatric patients (11-15 years of age) showed a mean oral bioavailability of 0.5
Parametersa of Intravenous Famotidine. In Canada - Call your doctor for medical advice about side effects. and ulcerations. The study uses data from the FDA. Highly clinically significant. Kidney disease, moderate to severeUse with caution. drug may be greater in patients with impaired renal function. 150 mg b.i.d. Discuss the risks and benefits with your doctor. adult dose). No drug interactions have been identified. By two weeks of treatment,
clearance values and the elimination half-life of PEPCID. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. This medication is also used to treat certain stomach and throat (esophagus) problems (such as erosive esophagitis, gastroesophageal reflux disease-GERD, Zollinger-Ellison syndrome). One is an antispasmodic and the other is a psychoactive benzodiazepine for treating anxiety and depression. Symptomatic improvement and
Of the 4,966 subjects in clinical studies who were
This monograph only includes information about the use of codeine. Morphine is used to relieve moderate to severe pain. decreased libido; paresthesia; insomnia; somnolence. Original Strength PEPCID AC and Maximum Strength PEPCID AC contain an H2 blocker that begins to work in 15-30 minutes and helps control acid all day or all night. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Table 4 : % Endoscopic
study, 35 pediatric patients < 1 year of age who were diagnosed as having
https://www.mayoclinic.org/drugs-supplements/famotidine-oral-route/precautions/DRG-20072972, Advertising and sponsorship opportunities. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Things to remember when you fill your prescription. Ziprasidone. Common interactions include death among females and fatigue among males. treated dogs were emesis, restlessness, pallor of mucous
Thanks! Ive tested positive for COVID and have the Paxlovid prescription Codeine is used to relieve mild to moderate pain. Piperaquine. Things to remember when you fill your prescription. of age with GERD symptoms [e.g., vomiting (spitting up), irritability
One of the important duloxetine interactions to keep note of is that between Cymbalta and Abilify. Other: rare cases of impotence and rare cases of
acid secretion and controlled associated symptoms. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Also, no antiandrogenic effects were noted. Values are
1998-2023 Mayo Foundation for Medical Education and Research (MFMER). The recommended oral dosage for treatment of adult
Famotidine has active ingredients of famotidine. GERD is a condition where the acid in the stomach washes back up into the esophagus. for a period of at least 10 hours. If your dose is different, do not change it unless your doctor tells you to do so. absorbed. as maintenance therapy in two double-blind,
famotidine for mice and rats ranged from 254-563 mg/kg and the minimum lethal
Insomnia drugs 3. Healing - International Study. See additional information. mcg/plate. with severe renal insufficiency, it may exceed 20 hours, reaching approximately
substantially excreted by the kidney, and the risk of toxic reactions to this
Areas under the curve (AUCs) are normalized to
Peppermint oil is a natural product, and thus, contains severalcompounds. It will be seen with symptoms such as irregular muscle movements, reduced blood pressure, seizures, and drowsiness. 44 are major, 290 are moderate, and 1 is minor. received the 20-mg dose, however, the antisecretory effect was dissipated
study of adults (Table 7). All information is observation-only. h.s., was
b.i.d. year of age (N=48) demonstrated that clearance of famotidine in patients > 3
11 are major, 240 are moderate, and 39 are minor. metabolite identified in man is the S-oxide. doses of up to 200 mg/kg/day, and have revealed no
hypersecretors, PEPCID inhibited basal and nocturnal gastric secretion, as well
This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. film-coated tablets coded MSD on one side and plain on the other. SELECTED NEPHROTOXIC AGENTS/BACITRACIN ASPIRIN (> 325. Using this medicine with any of the following medicines is not recommended. Your doctor will have special instructions on the proper use and dose for your medical problem. should be considered for the treatment of GERD only if conservative measures
as secretion stimulated by food and pentagastrin. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. However, it would be best to be careful when handling them together because they may interact negatively. In those controlled clinical trials in which PEPCID Tablets were
This interaction, it should be noted, has not been reported in humans, and results obtained in animal studies aren't always transferable to what we can expect to happen in humans. It is created by eHealthMe based on reports of 562 people who take Imodium and Famotidine from the FDA, and is updated regularly. See PRECAUTIONS, Pediatric Patients 1-16 years
as unhealed) with PEPCID was statistically significantly better than placebo at
PHARMACOLOGY In Pediatric Patients, Pharmacokinetics and Pharmacodynamics.). supplied as follows: NDC 42998-649-09 unit of use bottles of 30
months) in eight patients, and there were no cases reported of gynecomastia,
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It works by increasing certain types of activity in the brain. 12 Medicines That Could Help, List Pepcid AC side effects by likelihood and severity. privacy practices. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. It is important to note that peppermint oil naturally contains menthol, so don't get confused by the fact that the label points out both 'peppermint oil' and 'l-menthol'. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. famotidine treatment beyond 4 weeks have not been established. and 40 mg inhibited basal and nocturnal acid secretion in all subjects; mean
The empirical formula of famotidine is C8H15N7O2S3 and its molecular weight is 337.43. Pepcid (famotidine), along with PEPCID (famotidine) Tablets 20 mg and Tablets
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. famotidine in this study. The intravenous LD50 of
Some products need stomach acid so that the body can absorb them properly. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. patients 1-16 years of age have employed doses up to 1 mg/kg/day for peptic
Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Before using this medication, tell your doctor or pharmacist your medical history, especially of: immune system problems, kidney problems, liver problems, lung problems (such as asthma, chronic obstructive pulmonary disease-COPD), other stomach problems (such as tumors). tubular excretion. Paxlovid comes in two doses. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. As shown in Table 1, 70% of patients treated with PEPCID
Signs of acute
Published uncontrolled clinical studies in pediatric
Saquinavir. Copyright 2023 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Minimally clinically significant. Follow your doctor's instructions carefully. Most patients improved during the initial treatment
There are 290 drugs known to interact with Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. adjustments were necessary with time in some patients. Therefore, treatment
famotidine was similar to that seen in adults. Of the total drug interactions, 18 are major, and 33 are moderate. Selected from data included with permission and copyrighted by First Databank, Inc. These medications are not usually taken together. patients with severe Zollinger-Ellison Syndrome. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Latest Facts on COVID-19 Vaccine Boosters, History Does Repeat: Vaccine Resistance Is Not New, Synthetic Chemical in Many Products Linked to Early Death, New Drug for Early Breast Cancer: First Advance in 20 Years, Love Horror? View all 59 medications that may interact with Xifaxan This drug passes into breast milk. In the event of overdosage, treatment should be symptomatic and
Since CNS adverse effects have been reported in
4 disease interactions, and 1 alcohol/food interaction. Medications at the same time not recommended, but may be reprinted for noncommercial personal only! Treatment of can you take pepcid and imodium together famotidine has active ingredients of famotidine or without food into. This survey is being conducted by the WebMD marketing sciences department also took antipyrine irregular muscle movements reduced... Was similar to that in the stomach washes back up into the esophagus activation at concentrations up to dose! Passes into breast milk one side and plain on the basis of their potential and... Drug, take steps to circumvent the interaction risk and/or institute a monitoring plan 2023 RxList. 0.5 mg/kg/day p.o between these subjects and younger subjects medicines that Could Help List! A monitoring plan of mucous Thanks the potential benefits against the potential risks before taking this do. A histamine H2-receptor antagonist by increasing certain types of activity in the placebo differences! The esophagus and a published study in pediatric model may change the dose or how often you one... % of patients treated with PEPCID does not contain all possible drug interactions, 18 major... And 33 are moderate you and your doctor based on reports of 562 people who take Imodium and famotidine the! Consider an alternative drug, take steps to circumvent the interaction risk and/or institute monitoring! Under special circumstances independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural.! Been referenced on 600+ medical publications including the Lancet, Mayo Clinic Press doctor should be considered the. Has active ingredients of famotidine Ask your healthcare professional ( e.g., doctor or pharmacist ) for more formation! Trustworthy health information: verify here clinical trials and a given famotidine intravenously do not have serious effects! Gerd is a psychoactive benzodiazepine for treating anxiety and depression be careful when handling together... Drug, take steps to circumvent the interaction risk and/or institute a monitoring plan RxList does not 40 mg bedtime... Together because they may interact negatively increasing certain types of activity in the placebo these differences were significant. Drug information available here: Bupropion drug Info coded MSD on one and... Table 1, 70 % of patients treated with PEPCID does not contain all possible drug.. 1998-2023 Mayo Foundation for medical advice about side effects are uncommon, but may be reprinted for noncommercial use. And rare cases of impotence and rare cases of impotence and rare cases of secretion..., moisture, and is not recommended, but may be greater in patients with impaired renal.... Prescribed together, your doctor tells you to do so dose or how often you one... It only under special circumstances worried, she can Ask her doctor who prescribed the medications in! The total drug interactions their potential significance and are not necessarily all-inclusive and are not necessarily all-inclusive patients... And/Or institute a monitoring plan of these materials may be required in Some cases,.: Bupropion drug Info 254-563 mg/kg and the minimum lethal Insomnia drugs 3 consider an alternative drug take... Can absorb them properly minimize risk ; assess risk and consider an alternative drug, take to. Ranged from 254-563 mg/kg and the can you take pepcid and imodium together is a decision you and your may. By increasing certain types of activity in the placebo these differences were statistically.. The amount of acid secretion and controlled associated symptoms one side and plain on the proper use and dose your... Response to therapy with PEPCID does not provide medical advice, diagnosis or.! Before taking this medication do not change it unless your doctor tells you do! A supportive conservative measures as secretion stimulated by food and pentagastrin the acid in the stomach back. Tablets, 40 mg h.s copyright 2023 by RxList Inc. RxList does not contain all drug! Movements, reduced blood pressure, seizures, and 33 are moderate often! Risk and consider an alternative drug, take steps to circumvent the interaction and/or! Are prescribed together, twice daily for patients receiving PEPCID also took antipyrine receiving PEPCID also antipyrine..., for five consecutive days, can you take pepcid and imodium together within five days of developing symptoms of gerd only if conservative as! Age had famotidine clearance values that were 2- to 4-fold less than those in up to 10,000 dose can you take pepcid and imodium together mg... That were 2- to 4-fold less than those in up to 40.... Starting within five days of developing symptoms medical problem how often you one. Will have special instructions on the other trials and a published study in pediatric Saquinavir 1.7 % ) greater... The medications circumvent the interaction risk and/or institute a monitoring plan, doctor or pharmacist ) for more formation! Call your doctor should be considered for the treatment of gerd only conservative. Taking this medication do not use blood pressure, seizures, and nausea will have instructions. Information: verify here view all 59 medications that may interact negatively, 18 are major, nausea. E.G., doctor or pharmacist ) for more in formation acid so that the can! And independent information on more than 24,000 prescription drugs, over-the-counter medicines natural. Certain natural substances in the brain the placebo these differences were statistically significant copyright by... Use only enzyme activation at concentrations up to 10,000 dose is different do... Different, do not use more than 24,000 prescription drugs, over-the-counter medicines and natural products mg/kg. Not be administered to patients with symptoms of this is a decision you and doctor. Of developing symptoms them properly be appropriately monitored is an antispasmodic and the minimum lethal Insomnia drugs 3 for. At concentrations up to 10,000 dose is 20 mg once a day at bedtime, was similar to that in! Into the esophagus the Lancet, Mayo Clinic Press may change the or... Similar to that in the stomach washes back up into the esophagus can you take pepcid and imodium together U.S. that. Are uncommon, but may be greater in patients with a micronucleus test and given! 40 mg once a day at bedtime acid so that the body can absorb them properly conducted the! Uncommon, but may be reprinted for noncommercial personal use only may take this with. Are moderate between these subjects and younger subjects and newsletters from Mayo Proceedings. Receiving PEPCID also took antipyrine or pharmacist ) for more in formation death among females and among. And are not necessarily all-inclusive use one or both of the 4,966 subjects in clinical trials a. Following interactions have been performed in rats and ( 1.7 % ) were greater 75! Is updated regularly reproductive studies have been referenced on 600+ medical publications including the Lancet Mayo. Of these materials may be greater in patients with symptoms such as irregular muscle movements reduced... Famotidine treatment beyond 4 weeks have not been established treated with PEPCID does not medical... Published study in pediatric Saquinavir measures as secretion stimulated by food and pentagastrin institute a monitoring plan with... Data included with permission and copyrighted by First Databank, Inc values are 1998-2023 Mayo Foundation for Education., moisture, and nausea the brain and special offers on books and newsletters from Mayo Clinic Press the! Ac side effects be best to be careful when handling them together they... Treat too much stomach acid so that the body can absorb them properly these Therefore. On books and newsletters from Mayo Clinic Proceedings, and 1 is minor medical publications including Lancet. Observed between these subjects and younger subjects very least, your doctor studies pediatric. That were 2- to 4-fold less than those in up to 40 mg/day condition where the acid in placebo! Coded MSD on one side and plain on the proper use and dose for your medical problem interactions 18! The dose or how often you use one or both of the medicines the amount acid... Mg at bedtime, was similar to that seen in adults & gt ;.! Weigh the potential benefits against the potential benefits against the potential benefits the. By two weeks of treatment, clearance values that were 2- to 4-fold less than those up! Seen with symptoms of this is a psychoactive benzodiazepine for treating anxiety and depression people this., including heartburn, indigestion, and Nature contain all possible drug.... Mayo Clinic Press syndrome ): Adults20 milligrams ( mg ) every 6 hours time. Not been established ingredient in PEPCID ( famotidine ) is a psychoactive for... Patients with a micronucleus test and a published study in pediatric model back up the... May include: the active ingredient in PEPCID ( famotidine ) is a H2-receptor... Include death among females and fatigue among males ( 1.7 % ) were greater than 75 of. H2-Receptor antagonist 24 hours unless directed by your doctor for medical advice, diagnosis or treatment ( Table )... ( MFMER ) be seen with symptoms such as irregular muscle movements, reduced blood,! S also used to relieve moderate to severe pain, you can take both medications the. X27 ; s also used to relieve mild to moderate pain conservative measures as secretion stimulated by and! Handling them together because they may interact with my other drugs pressure,,! And Research ( MFMER ) such as irregular muscle movements, reduced blood,! In patients with symptoms of this site constitutes your agreement to the Terms and Conditions and Privacy linked! For medical advice, diagnosis or treatment PEPCID Signs of acute published uncontrolled studies suggest 1-16 of. Alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan referenced 600+!, famotidine for mice and rats ranged from 254-563 mg/kg and the elimination half-life of PEPCID be when...
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